Hacker News on Thursday, 26 June 2025

AlphaGenome: AI for better understanding the genome(deepmind.google)

505 points by i_love_limes 1 year ago | 168 comments

Google DeepMind blog post announcing AlphaGenome, an AI model for predicting how DNA sequence variants affect gene regulation and genome function.

Alternative Layout System(alternativelayoutsystem.com)

367 points by smartmic 1 year ago | 64 comments

Alternative Layout System is a site offering typographic layout scripts like Same Sizer and Wiggle Out that use variable fonts to fit words and lines in unconventional ways.

Introducing Gemma 3n(developers.googleblog.com)

361 points by bundie 1 year ago | 159 comments

Google for Developers blog post introducing Gemma 3n, a developer guide to Google's new on-device open model.

Launch HN: Issen (YC F24) – Personal AI language tutor

298 points by mariano54 1 year ago | 263 comments

US economy shrank 0.5% in the first quarter, worse than earlier estimates(apnews.com)

275 points by Aloisius 1 year ago | 94 comments

Why is the Rust compiler so slow?(sharnoff.io)

269 points by Bogdanp 1 year ago | 353 comments

Snow - Classic Macintosh emulator(snowemu.com)

268 points by ColinWright 1 year ago | 88 comments

The first non-opoid painkiller(worksinprogress.news)

201 points by ortegaygasset 1 year ago | 144 comments

The time is right for a DOM templating API(justinfagnani.com)

199 points by mdhb 1 year ago | 204 comments

LLM code generation may lead to an erosion of trust(jaysthoughts.com)

194 points by CoffeeOnWrite 1 year ago | 217 comments

A.I. Is Homogenizing Our Thoughts(newyorker.com)

184 points by thoughtpeddler 1 year ago | 56 comments

Revisiting Knuth's “Premature Optimization” Paper(probablydance.com)

176 points by signa11 1 year ago | 109 comments

Starcloud can’t put a data centre in space at $8.2M in one Starship(angadh.com)

173 points by angadh 1 year ago | 294 comments

Matrix v1.15(matrix.org)

170 points by todsacerdoti 1 year ago | 62 comments

The Book of Shaders (2015)(thebookofshaders.com)

170 points by max_ 1 year ago | 23 comments

Learnings from building AI agents(cubic.dev)

147 points by pomarie 1 year ago | 57 comments

Show HN: I built an AI dataset generator(github.com)

140 points by matthewhefferon 1 year ago | 28 comments

Lateralized sleeping positions in domestic cats(cell.com)

122 points by EvgeniyZh 1 year ago | 53 comments

FLUX.1 Kontext [Dev] – Open Weights for Image Editing(bfl.ai)

117 points by minimaxir 1 year ago | 34 comments

Show HN: Magnitude – Open-source AI browser automation framework(github.com)

113 points by anerli 1 year ago | 38 comments

A glob of 99M-year-old amber trapped a zombie fungus erupting from a fly(cnn.com)

111 points by jackgavigan 1 year ago | 57 comments

Kea 3.0, our first LTS version(isc.org)

107 points by conductor 1 year ago | 40 comments

AI Is Dehumanization Technology(thedabbler.patatas.ca)

98 points by smartmic 1 year ago | 65 comments

Apptainer: Application Containers for Linux(apptainer.org)

91 points by cl3misch 1 year ago | 55 comments

Muvera: Making multi-vector retrieval as fast as single-vector search(research.google)

89 points by georgehill 1 year ago | 7 comments

Games That Weren't: Preserving Cancelled and Unreleased Video Game History(gamesthatwerent.com)

82 points by ibobev 1 year ago | 14 comments

Robots that learn(openai.com)

82 points by ulrischa 1 year ago | 24 comments

I fought in Ukraine and here's why FPV drones kind of suck(warontherocks.com)

81 points by _tk_ 1 year ago | 115 comments

A Review of Aerospike Nozzles: Current Trends in Aerospace Applications(mdpi.com)

80 points by PaulHoule 1 year ago | 43 comments

I built an ADHD app with interactive coping tools, noise mixer and self-test(adhdhelp.app)

80 points by digitalions 1 year ago | 64 comments

Memory safety is table stakes(usenix.org)

79 points by comradelion 1 year ago | 81 comments

Ultrasound toothbrush promises painless checks for hidden gum problems(phys.org)

75 points by PaulHoule 1 year ago | 48 comments

Why Go Rocks for Building a Lua Interpreter(zombiezen.com)

71 points by Bogdanp 1 year ago | 37 comments

Senators reintroduce App Store bill to rein in 'gatekeeper power'(9to5mac.com)

60 points by janandonly 1 year ago | 38 comments

What UI first distinguished radio buttons from checkboxes with circles/squares?(retrocomputing.stackexchange.com)

59 points by azeemba 1 year ago | 37 comments

Shifts in diatom and dinoflagellate biomass in the North Atlantic over 6 decades(journals.plos.org)

57 points by PaulHoule 1 year ago | 3 comments

Access BMC UART on Supermicro X11SSH(github.com)

57 points by pietrushnic 1 year ago | 12 comments

Apple announces sweeping App Store changes in the EU(9to5mac.com)

53 points by saubeidl 1 year ago | 37 comments

Slightly better named character reference tokenization than Chrome, Safari, FF(ryanliptak.com)

53 points by todsacerdoti 1 year ago | 8 comments

Save your disk, write files directly into RAM with /dev/shm(hiandrewquinn.github.io)

47 points by hiAndrewQuinn 1 year ago | 52 comments

How to Leave the House(buttondown.com)

43 points by zdw 1 year ago | 39 comments

Tennis Scorigami(tennis-scorigami.com)

41 points by jlarks32 1 year ago | 6 comments

The Perils of 'Design Thinking'(theatlantic.com)

40 points by Petiver 1 year ago | 37 comments

RSS Server Side Reader(matklad.github.io)

37 points by Bogdanp 1 year ago | 39 comments

Show HN: I built a daily sunlight tracker(lumehealth.io)

36 points by vickipow 1 year ago | 23 comments

Show HN: Rust -> WASM, K-Means Color Quantization Crate for Image-to-Pixel-Art(github.com)

34 points by gametorch 1 year ago | 4 comments

The European wood pigeon helped me appreciate its omnipresent city cousins(nytimes.com)

33 points by Thevet 1 year ago | 2 comments

Philadelphia Transit System Votes to Cut Service by 45%, Hike Fares(bloomberg.com)

32 points by petethomas 1 year ago | 20 comments

As AI kills search traffic, Google launches Offerwall to boost publisher revenue(techcrunch.com)

29 points by elektor 1 year ago | 31 comments

Thomas Aquinas – The world is divine(ralphammer.com)

28 points by pedroth 1 year ago | 12 comments

Ticket-Driven Development: The Fastest Way to Go Nowhere(thecynical.dev)

26 points by EdwardDiego 1 year ago | 15 comments

Building untrusted container images safely at scale(depot.dev)

24 points by Telstrom90 1 year ago | 19 comments

Show HN: SVG Lined Tile Generator(adpreese.github.io)

20 points by adpreese 1 year ago | 4 comments

Mixed DPI in X11(wok.oblomov.eu)

19 points by somat 1 year ago | 5 comments

Show HN: PRSS Site Creator – Create Blogs and Websites from Your Desktop(prss.co)

17 points by volted 1 year ago | 7 comments

Show HN: Summle – A little maths Game(summle.net)

17 points by kirchhoff 1 year ago | 6 comments

E.A. Spitzka's Studies of Exceptional and Deviant Brains (2024)(huntington.org)

13 points by Hooke 1 year ago | 1 comments

AI Improves at Improving Itself Using an Evolutionary Trick(spectrum.ieee.org)

11 points by pseudolus 1 year ago | 7 comments

Welsh publisher brings Tolkien classic in Celtic languages together(nation.cymru)

11 points by p_ing 1 year ago | 0 comments

Oldest boomerang doesn't come back(bbc.co.uk)

5 points by ljf 1 year ago | 4 comments