Baby is healed with first personalized gene-editing treatment(nytimes.com)
1122 points by jbredeche | 470 comments
New York Times article about a baby treated with the first personalized gene-editing therapy for a rare genetic disorder.
Hacker News on
Stories posted this day, by points. Rank history starts with the October 2026 rebuild.
Human(quarter--mile.com)
640 points by surprisetalk | 249 comments
A short satirical fiction essay imagining a machine world where a group called OpenHuman tries to build 'Organic General Intelligence'—humans.
I don't like NumPy(dynomight.net)
399 points by MinimalAction | 164 comments
A Dynomight blog essay critiquing NumPy's design, arguing its array broadcasting and indexing make complex computations confusing.
The unreasonable effectiveness of an LLM agent loop with tool use(sketch.dev)
392 points by crawshaw | 258 comments
A sketch.dev blog post explaining how a simple loop of LLM calls with tool use powers their AI programming assistant, Sketch.
A leap year check in three instructions(hueffner.de)
386 points by gnabgib | 130 comments
Blog post by Falk Hüffner explaining a leap year check for years 0–102499 using a multiply, mask, and compare in about three CPU instructions.
Coinbase says hackers bribed staff to steal customer data, demanding $20M ransom(cnbc.com)
372 points by gpi | 450 comments
CNBC news article reporting that hackers bribed Coinbase staff to steal customer data and are demanding a $20 million ransom.
Malicious compliance by booking an available meeting room(clientserver.dev)
349 points by jakevoytko | 330 comments
A Client/Server newsletter post recounting how Googlers used Google Calendar room booking to subvert Larry Page's 2011 meeting policies.
LLMs get lost in multi-turn conversation(arxiv.org)
330 points by simonpure | 206 comments
arXiv paper showing top LLMs perform about 39% worse in multi-turn, underspecified conversations than in single-turn, fully specified settings.
A Tiny Boltzmann Machine(eoinmurray.info)
245 points by anomancer | 42 comments
Llama from scratch (2023)(blog.briankitano.com)
136 points by sebg | 2 comments
Show HN: Real-Time Gaussian Splatting(github.com)
124 points by markisus | 44 comments
Pathfinding(juhrjuhr.itch.io)
123 points by sebg | 40 comments
Popcorn: Run Elixir in WASM(popcorn.swmansion.com)
122 points by clessg | 22 comments
My Engineering Craft Regressed(lemmy.ml)
93 points by OsrsNeedsf2P | 46 comments
Refactoring Clojure(orsolabs.com)
85 points by luu | 21 comments
MicroPython v1.25.0(github.com)
72 points by todsacerdoti | 12 comments
O(n) vs. O(n^2) Startups(rohan.ga)
64 points by ocean_moist | 65 comments
An Update on Fresh(deno.com)
62 points by agos | 47 comments
Magic Leap One Bootloader Exploit(github.com)
62 points by mmastrac | 4 comments
Model Organisms Are Not Static(asimov.press)
30 points by mailyk | 8 comments