The entire city of San Francisco as a video game(sf.thijs.gg)

569 points by centrosphere 2 months ago | 164 comments

A browser-based interactive 3D game rendering the entire city of San Francisco, shown here on its loading screen.

Show HN: What should the GUI for AI agents look like?(marbleos.com)

91 points by akbabu 2 months ago | 55 comments

Wii U SDBoot1 Exploit “paid the beak”(consolebytes.com)

159 points by sjuut 1 year ago | 26 comments

The 100 hour gap between a vibecoded prototype and a working product(kanfa.macbudkowski.com)

219 points by kiwieater 7 months ago | 291 comments

Show HN: ULDA – Client-side encryption with a simple JavaScript API(demo.ulda.io)

17 points by nonsence 7 days ago | 3 comments

Interactive demo of the ULDA SDK: a room-planner app whose data is client-side encrypted and synced, with an inspector comparing decrypted JSON to server ciphertext.

How to improve your WFH lighting to reduce eye strain(rustle.ca)

615 points by jahfer 1 year ago | 279 comments

An article on improving home office lighting to reduce eye strain, illustrated with a 3D-rendered room showing lamps and a desk setup.

The Genocide Economy, Mapped(bl00d.money)

3 points by khaled_ismaeel 14 days ago | 0 comments

An interactive data visualization site, bl00d.money, that maps the companies and money flows it describes as profiting from genocide.

How much of Thermo Fisher's antibody data has been manipulated?(reeserichardson.blog)

411 points by mhrmsn 4 months ago | 88 comments

Blog post by Reese Richardson investigating apparent image manipulation in Thermo Fisher's antibody product validation data.

A DIY ‘bionic pancreas’ is changing diabetes care(nature.com)

446 points by sohkamyung 3 years ago | 160 comments

A Nature news feature from August 2023 about DIY 'bionic pancreas' closed-loop insulin systems built by people with diabetes and what comes next.

Cheap blood test detects pancreatic cancer before it spreads(nature.com)

331 points by rbanffy 1 year ago | 196 comments

Nature news article from February 2025 about an inexpensive blood test that can detect pancreatic cancer before it spreads to other parts of the body.

Nobel Prize in Physiology or Medicine 2026(nobelprize.org)

6 points by marc__1 21 days ago | 2 comments

The official Nobel Prize website's landing page for the Nobel Prize in Physiology or Medicine.

23andMe confirms hackers stole ancestry data on 6.9M users(techcrunch.com)

456 points by helsinkiandrew 2 years ago | 233 comments

TechCrunch article reporting that 23andMe confirmed hackers stole ancestry data belonging to about 6.9 million users.